Munzvimbo yekutsvagisa sainzi, kunyanya muminda yakaita sebiochemistry, cell biology, uye pharmacology, kusarudzwa kwemidziyo yemurabhoritari kunogona kukanganisa zvakanyanya kushanda uye kurongeka kwekuyedza. Imwe sarudzo yakakosha ndeyekusarudzwa pakati pe96-tsime uye 384-matsime mahwendefa. Mhando mbiri dzeplateti dzine seti dzadzo dzezvakanakira uye zvinogona kukanganisa. Kiyi yekugonesa kushanda kwelabhu iri mukunzwisisa misiyano iyi uye kusarudza iyo inonyatsoenderana nezvinodiwa chaizvo zvekuyedza.

1. Vhoriyamu uye Kuburikidza

Imwe yemisiyano yekutanga pakati pe96-tsime uye 384-matsime mahwendefa huwandu hwematsime, ayo anokanganisa zvakananga huwandu hwemareagents anogona kushandiswa uye kuburikidza nekubuda kwekuyedza. Indiro ye96-tsime, ine matsime akakura, inowanzobata vhoriyamu yakawanda, ichiita kuti ive yakakodzera bvunzo dzinoda mamwe mareagents kana masampuli, uye yekuedza uko kuvharika kungave kunetseka. Sezvineiwo, mahwendefa e384-tsime, ane huwandu hwepamusoro hwematsime, anobvumira kuwanda kwenhamba yekuongorora panguva imwe chete, nekudaro ichiwedzera kubuda zvakanyanya. Izvi zvinonyanya kubatsira mu-high-throughput screening (HTS) zvikumbiro, uko kukwanisa kugadzirisa nhamba huru yemasampuli nokukurumidza kwakakosha.

2. Kushanda Kwemari

Mutengo ndechimwe chinhu chakakosha kufunga. Nepo 384-tsime mahwendefa achiwanzo bvumidza mamwe maassays pandiro, izvo zvinogona kuderedza mutengo payeyedzo, ivo vanogona zvakare kuda yakanyatsojeka uye kazhinji inodhura midziyo yekubata mvura. Pamusoro pezvo, mavhoriyamu madiki reagent anoshandiswa mu384-tsime mahwendefa anogona kutungamira mukukosha kwekuchengetedza mari pamareagents nekufamba kwenguva. Nekudaro, maLab anofanirwa kuenzanisa mari iyi nekudyara kwekutanga mune yakawedzera midziyo.

3. Sensitivity uye Data Quality

Kunzwa kwemaassays anoitwa mu96-zvakanaka maringe ne384-tsime mahwendefa anogonawo kusiyana. Kazhinji, vhoriyamu yakakura mumaplateti e96-tsime inogona kubatsira kuderedza kusiyanisa uye kuwedzera kuberekana kwemhedzisiro. Izvi zvinoita kuti vakwanise kuyedza uko kurongeka kwakakosha. Kune rimwe divi, 384-tsime mahwendefa, ane mavhoriyamu madiki, anogona kuwedzera sensitivity mune mamwe maassays, akadai sefluorescence kana luminescence-based assays, nekuda kwekukwira kwechiratidzo.

4. Space Utilization

Nzvimbo yerabhoritari inowanzove yakakosha, uye sarudzo yeplate inogona kukanganisa mashandisirwo enzvimbo iyi nemazvo. 384-tsime mahwendefa anogonesa kumwe kuongorora kuti kuitwe munzvimbo imwe chete yemuviri zvichienzaniswa ne96-tsime mahwendefa, zvinobudirira kuwedzera lab bhenji uye incubator nzvimbo. Izvi zvinogona kunyanya kubatsira mumaLab ane nzvimbo shoma kana uko kukwirisa-kuburikidza kwakakosha.

5. Equipment Compatibility

Kuenderana nemidziyo yelab iripo ndeimwe yakakosha kufunga. Marabhoritari mazhinji atove nemidziyo yakarongedzerwa ku96-tsime mahwendefa, kubva kumarobhoti anopopa kuenda kune vanoverenga ndiro. Kuchinjisa kune 384-mutsime mahwendefa kungangoda michina mitsva kana kugadziridzwa kune iripo masisitimu, ayo anogona kudhura uye kutora nguva. Naizvozvo, maLab anofanirwa kunyatso ongorora kana mabhenefiti ekuchinja kune 384-matsime mahwendefa anopfuura aya matambudziko anogona kuitika.

Mhedziso

Pakupedzisira, sarudzo pakati pekushandisa 96-tsime kana 384-tsime ndiro inotsamira pane chaizvo zvinodiwa murabhoritari uye chimiro chezviedzo zviri kuitwa. Kune zviedzo zvinoda mavhoriyamu akakura uye uko kunzwisiswa uye kuberekana kwakakosha, 96-matsime mahwendefa anogona kunge ari sarudzo iri nani. Sezvineiwo, kune yakakwirira-kuburikidza maapplication uye mutengo unoshanda maererano nekushandisa reagent, 384-tsime mahwendefa anogona kuwedzera zvakanyanya kushanda kwerabhoritari. Marabhoritari anofanira kuyera zvinhu izvi nokungwarira, achifunga nezvemamiriro azvo akasiyana, kuti aite sarudzo ine ruzivo uye inoshanda.