Nsonga yodzichepetsa ya pipette ndi yaying'ono, yotsika mtengo, komanso yofunika kwambiri kwa sayansi. Imapatsa mphamvu kafukufuku wamankhwala atsopano, kuwunika kwa Covid-19, ndi kuyezetsa magazi kulikonse komwe kumachitika.
Zilinso, nthawi zambiri, zambiri - wasayansi wa benchi amatha kugwira ambiri tsiku lililonse.
Koma tsopano, zopumira zingapo zokhala ndi nthawi yoyipa motsatira njira zoperekera nsonga za pipette - zolimbikitsidwa ndi kuzimitsidwa, moto, komanso kufunikira kokhudzana ndi miliri - zapangitsa kuchepa kwapadziko lonse komwe kukuwopseza pafupifupi mbali zonse za sayansi.
Kuperewera kwa nsonga za pipette kukuyika kale pachiwopsezo mapulogalamu m'dziko lonselo omwe amawunikira ana obadwa kumene kuti ali ndi vuto lakupha, monga kulephera kugaya shuga mu mkaka wa m'mawere. Ndikuwopseza kuyesa kwa mayunivesite pa stem cell genetics. Ndipo ikukakamiza makampani opanga zamankhwala omwe akupanga mankhwala atsopano kuti aganizire zoyika zoyeserera zina patsogolo pa ena.
Pakalipano, palibe chizindikiro chakuti kuchepaku kutha posachedwa - ndipo ngati ziipiraipira, asayansi angafunike kuyamba kuyimitsa zoyeserera kapena kusiya mbali zina za ntchito yawo.
Mwa asayansi onse amene sanachite mantha ndi kupereŵeraku, ofufuza amene ali ndi udindo wofufuza ana akhanda ndiwo ndiwo anali olinganiza bwino ndiponso olankhula mosapita m’mbali.
Ma laboratories azachipatala amawunika makanda pasanathe maola angapo atabadwa kuti adziwe zambiri za momwe majini alili. Ena, monga phenylketonuria ndi kuchepa kwa MCAD, amafuna kuti madokotala asinthe nthawi yomweyo momwe akusamalira mwanayo. Ngakhale kuchedwa chabe pakuwunika kwapangitsa kuti ana akhanda afe, malinga ndi kafukufuku wa 2013.
Kuyezetsa kwa mwana aliyense kumafuna malangizo a pipette 30 mpaka 40 kuti amalize mayeso ambirimbiri, ndipo ana masauzande amabadwa tsiku lililonse ku United States.
Kumayambiriro kwa mwezi wa February, ma laboratorieswa anali kuwonetsa kuti alibe zinthu zomwe amafunikira. Ma Lab m'maboma 14 ali ndi malangizo ochepera mwezi umodzi otsala, malinga ndi Association of Public Health Laboratories. Gululi lidakhudzidwa kwambiri kotero kuti, kwa miyezi ingapo, lakakamiza boma la feduro - kuphatikiza White House - kuti liyike patsogolo zosowa za pipette zamapulogalamu owunika obadwa kumene. Pakadali pano, bungweli likuti, palibe chomwe chasintha; a White House adauza STAT kuti boma likuyesetsa njira zingapo zowonjezerera kupezeka kwa maupangiri.
M'madera ena, kuchepa kwa mapulasitiki "kwachititsa kuti magawo ena a mapulogalamu oyeza ana obadwa kumene atseke," atero a Susan Tanksley, woyang'anira nthambi mu gawo la labotale ya dipatimenti ya zaumoyo ku Texas, pamsonkhano wa February wa komiti ya advisory ya federal pakuwunika obadwa kumene. . (Tankskey ndi dipatimenti ya zaumoyo m'boma sanayankhe pempho loti apereke ndemanga.)
Mayiko ena akulandila maupangiri kwangotsala tsiku limodzi kuti apulumuke, zomwe zimawasiyira mwayi wosankha koma kupempha ma lab ena kuti asungire zosunga zobwezeretsera, malinga ndi a Scott Shone, mkulu wa labotale yazaumoyo ku North Carolina. A Shone anati anamvapo za akuluakulu azaumoyo akuimbira foni “akunena kuti, 'Mawa nditha, kodi mungandigonerepo kanthu?' Chifukwa wogulitsa akuti ikubwera, koma sindikudziwa.’”
"Kukhulupirira pamene wogulitsayo akuti, 'Masiku atatu musanathe, tidzakupezerani mwezi wina' - ndi nkhawa," adatero.
Ma lab ambiri atembenukira ku njira zina zokhomeredwa ndi jury. Ena akutsuka nsonga ndikuzigwiritsanso ntchito, zomwe zimawonjezera chiopsezo chotenga kachilomboka. Ena akuyesa kuwunika kobadwa kumene m'magulu, zomwe zitha kuwonjezera nthawi yomwe zimatengera kuti apereke zotsatira.
Mpaka pano, mayankho awa akhala okwanira. "Sitili mumkhalidwe womwe umakhala pachiwopsezo kwa ana obadwa kumene," anawonjezera Shone.
Kupitilira ma laboratories omwe amawunika makanda obadwa kumene, makampani opanga zida zamankhwala omwe amagwira ntchito zatsopano zamankhwala ndi ma laboratories aku yunivesite omwe akuchita kafukufuku wofunikira nawonso akumva kufinya.
Asayansi ku PRA Health Sciences, bungwe lofufuza za mgwirizano lomwe likugwira ntchito zoyesa zachipatala za matenda a chiwindi a B ndi anthu angapo omwe akufunafuna mankhwala a Bristol Myers Squibb, akuti zinthu zomwe zikutha ndikuwopseza nthawi zonse - ngakhale sanachedwe kuwerengera.
"Nthawi zina, zimatsikira ku nsonga imodzi yokhala pashelefu yakumbuyo, ndipo timakhala ngati 'Oh wanga wabwino,'" atero a Jason Neat, director wamkulu wa bioanalytical services pa labu ya PRA Health ku Kansas.
Kuperewera kwakhala kochititsa mantha mokwanira ku Arrakis Therapeutics, kampani ya Waltham, Mass. yomwe ikugwira ntchito zothandizira khansa, matenda a ubongo, ndi matenda osowa, kuti mkulu wake wa RNA biology, Kathleen McGinness, adapanga njira yodzipereka ya Slack kuti athandize anzake kugawana nawo. njira zotetezera nsonga za pipette.
"Tidazindikira kuti izi sizinali zovuta," adatero panjira, #tipsfortips. "Magulu ambiri akhala akukangana kwambiri ndi mayankho, koma tinalibe malo ogawana nawo."
Makampani ambiri a sayansi ya sayansi ya zamoyo omwe anafunsidwa ndi STAT adati akuchitapo kanthu kuti asunge ma pipette ochepa ndipo, mpaka pano, sanayimitse ntchito.
Asayansi a Octant, mwachitsanzo, akusankha kwambiri kugwiritsa ntchito nsonga za pipette zosefedwa. Malangizo awa - omwe ndi ovuta kupeza posachedwapa - amapereka zitsanzo zowonjezera chitetezo ku zowononga zakunja, koma sizingayeretsedwe ndi kugwiritsidwanso ntchito. Chifukwa chake amawapereka kuzinthu zomwe zingakhale zovuta kwambiri.
"Ngati simukusamala zomwe zikutha, mutha kutaya zinthu mosavuta," adatero Danielle de Jong, woyang'anira labu pa yunivesite ya Florida ku Whitney Laboratory; labu yomwe amagwira ntchito pofufuza momwe ma stem cell amagwirira ntchito mu nyama zazing'ono zam'madzi zokhudzana ndi nsomba za jellyfish zomwe zimatha kupanganso magawo ake.
Asayansi ku Whitney Laboratory, nthawi zina, adapereka ndalama kwa anansi awo pamene malamulo operekera sadafike mu nthawi; de Jong wadzigwira akuyang'ana mashelufu a ma lab ena kuti apeze malangizo aliwonse osagwiritsidwa ntchito, ngati labu yake ikufuna kubwereka.
Iye anati: “Ndakhala ndikugwira ntchito mu lab kwa zaka 21. “Sindinayambe ndakumanapo ndi vuto la ma suppliers ngati awa. Nthawi zonse.”
Palibe kufotokoza m'modzi kokha kwa kuchepaku.
Kuphulika kwadzidzidzi kwa mayeso a Covid-19 chaka chatha - chomwe chili chonse chimadalira maupangiri a pipette - adachitapo kanthu. Koma zotulukapo za masoka achilengedwe ndi ngozi zina zowopsa zomwe zikuchulukirachulukira pakugulitsa zidatsikiranso ku mabenchi a labotale.
Kuzimitsidwa kowopsa kwa dziko lonse ku Texas, komwe kudapha anthu opitilira 100, kudasokonezanso ulalo wovuta wamtundu wa pipette. Kuzimitsidwa kwa magetsi kumeneko kunakakamiza ExxonMobil ndi makampani ena kutseka kwakanthawi mbewu m'boma - zina zomwe zidapanga utomoni wa polypropylene, zopangira nsonga za pipette.
Malinga ndi ulaliki wa Marichi, chomera cha ExxonMobil ku Houston chinali chachiwiri pamakampani opanga polypropylene mu 2020; kokha chomera chake cha Singapore chinapanga zambiri. Ziwiri mwazomera zitatu zazikulu kwambiri za polyethylene za ExxonMobil zidapezekanso ku Texas. (Mu Epulo 2020, ExxonMobil idakulitsa kupanga polypropylene pamitengo iwiri yaku US.)
"Pambuyo pa mkuntho wachisanu mu February chaka chino, akuti oposa 85% ya mphamvu yopanga polypropylene ku US inakhudzidwa kwambiri chifukwa cha zinthu zosiyanasiyana monga kusweka mapaipi kumalo opangira zinthu komanso kutayika kwa magetsi ndi magetsi. zida zofunika kuti ayambitsenso kupanga, "atero mneneri wa Total, kampani ina yamafuta ndi gasi yaku Houston yomwe imapanga polypropylene.
Koma maunyolo ogulitsa akhala akugogomezedwa kuyambira chilimwe chatha - kusanakhale kozizira kwambiri kwa February. Kuchuluka kwa zinthu zopangira sizinthu zokhazo zomwe zikupangitsa kuti unyolo woperekera zakudya ukhale wosavuta - ndipo nsonga za pipette sindizo zida za labu zokha za pulasitiki zomwe zasowa.
Moto wopangira mafakitale udagwetsanso 80% ya zomwe dzikolo limapereka kwa nsonga za pipette zogwiritsidwa ntchito ndi zinthu zina zakuthwa, malinga ndi chikalata chomwe chinayikidwa pa webusayiti ya University of Pittsburgh.
Ndipo mu Julayi, US Customs and Border Protection idayamba kuletsa zinthu zopangidwa kuchokera kwa wopanga ma glovu akuluakulu omwe akuwaganizira kuti amawakakamiza kugwira ntchito. (CBP idapereka zomwe zapeza pakufufuza kwake mwezi watha.)
"Zomwe tikuwona ndi chilichonse chomwe chili mubizinesi yokhudzana ndi mapulasitiki - polypropylene, makamaka - mwina ndi backorder, kapena ikufunika kwambiri," idatero PRA Health Sciences' Neat.
Kufunikaku ndikokwera kwambiri kotero kuti mitengo yazinthu zina zosoŵa yakwera, malinga ndi a Tiffany Harmon, woyang'anira zogula pa labu ya PRA Health Sciences'bioanalytics ku Kansas.
Kampaniyo tsopano ikulipira 300% yochulukirapo pamagulovu kudzera mwa omwe amapereka mwanthawi zonse. Ndipo malangizo a PRA a pipette tsopano ali ndi ndalama zowonjezera. Mmodzi wopanga nsonga za pipette, yemwe adalengeza zowonjezera zowonjezera 4.75% mwezi watha, adauza makasitomala ake kuti kusuntha kunali kofunikira chifukwa mtengo wa zipangizo zapulasitiki unali pafupifupi kawiri.
Chowonjezera ku kukayikakayika kwa asayansi a labotale ndi njira ya ogawa yodziwira kuti ndi maoda ati omwe ayambe kudzazidwa - ntchito zomwe asayansi ochepa adanena kuti amazimvetsa bwino.
"Mabungwe a labotale akhala akufunsa kuyambira pachiyambi kuti atithandize kumvetsetsa momwe zisankhozi zimapangidwira," atero a Shone, omwe adatchula njira za ogulitsa kuti adziwe zomwe zagawika ngati "matsenga amtundu wakuda."
STAT idalumikizana ndi makampani opitilira khumi ndi awiri omwe amapanga kapena kugulitsa malangizo a pipette, kuphatikiza Corning, Eppendorf, Fisher Scientific, VWR, ndi Rainin. Awiri okha adayankha.
Corning anakana kuyankhapo, kutchula mapangano ogwirizana ndi makasitomala ake. MilliporeSigma, panthawiyi, adanena kuti amagawa ma pipettes poyambira, choyamba.
"Chiyambireni mliriwu, bizinesi yonse ya sayansi ya moyo yakhala ikufunidwa kwambiri ndi zinthu zokhudzana ndi Covid-19, kuphatikiza MilliporeSigma," wolankhulira kampani yayikulu yogawa zinthu zasayansi adauza STAT mu imelo. "Tikugwira ntchito 24/7 kuti tikwaniritse kufunikira kwazinthu izi komanso zomwe zimagwiritsidwa ntchito pofufuza zasayansi."
Ngakhale kuyesa kulimbikitsa njira zogulitsira, sizikudziwika kuti kuchepaku kutha nthawi yayitali bwanji.
Corning adalandira $ 15 miliyoni kuchokera ku Dipatimenti ya Chitetezo kuti apange maupangiri ena a pipette a 684 miliyoni pachaka kumalo ake ku Durham, NC Tecan, nayenso, akumanga malo opangira zinthu zatsopano ndi $ 32 miliyoni kuchokera ku CARES Act.
Koma izi sizingathetse vutoli ngati kupanga mapulasitiki kumakhalabe kotsika kuposa momwe amayembekezera. Ndipo palibe mwama projekitiwa omwe angathe kupanga malangizo a pipette kugwa kwa 2021 kusanachitike.
Mpaka nthawi imeneyo, oyang'anira ma laboratory ndi asayansi akufunitsitsa kusowa kwa pipettes ndi china chirichonse.
"Tidayambitsa mliriwu chifukwa cha ma swabs ndi media. Ndiyeno tinali ndi kusowa kwa reagents. Ndiyeno tinali ndi kusowa kwa mapulasitiki. Kenako tinalinso ndi kusowa kwa ma reagents, "adatero Shone waku North Carolina. "Zili ngati Tsiku la Groundhog."
Nthawi yotumiza: Feb-12-2022